Dimethyltrienolone

Dimethyltrienolone
Clinical data

Routes of administration	Oral
Identifiers
IUPAC name 7α,17α-Dimethylestra-4,9,11-trien-17β-ol-3-one
Synonyms	RU-2420; 7α,17α-Dimethyltrenbolone; 7α,17α-Dimethyl-δ^9,11-19-nortestosterone; 7α,17α-Dimethylestra-4,9,11-trien-17β-ol-3-one
CAS Number	10110-86-8
ChemSpider	23208745
Chemical and physical data
Formula	C₂₀H₂₆O₂
Molar mass	298.4192 g/mol
3D model (JSmol)	Interactive image
SMILES O([H])[C@]12C[C@@]11C=CC3=C4CCC(C=C4C[C@@](C)[C@@]3([H])[C@]1([H])CC2)=O
InChI InChI=1S/C19H21O2/c1-11-8-12-9-13(20)2-3-14(12)15-4-6-18-10-19(18,21)7-5-16(18)17(11)15/h4,6,9,16-17,21H,2-3,5,7-8,10H2,1H3/t16-,17+,18+,19+/m0/s1 Key:NGLUFHGQVKSOMP-WJFTUGDTSA-N

Dimethyltrienolone (developmental code name RU-2420) is a synthetic, orally active, extremely potent anabolic-androgenic steroid (AAS) and 17α-alkylated 19-nortestosterone (nandrolone) derivative which was never marketed for medical use. It has among the highest known affinity of any AAS for the androgen (and progesterone) receptors, and has been said to be perhaps the most potent AAS to have ever been developed.

Dimethyltrienolone is an extremely potent agonist of the androgen and progesterone receptors and hence AAS and progestogen. In animal bioassays, it was shown to possess more than 100 times the anabolic and androgenic potency of the reference AAS methyltestosterone. The drug is not a substrate for 5α-reductase or aromatase and so is not potentiated in so-called "androgenic" tissues like the prostate gland or skin and does not have any estrogenic activity. Due to its lack of estrogenicity, dimethyltrienolone has no propensity for causing estrogenic side effects like gynecomastia. Because of its C17α methyl group and very high resistance to hepatic metabolism, dimethyltrienolone is said to be exceedingly hepatotoxic.