Dihydroxyprogesterone acetophenide

Algestone acetophenide

Clinical data
Synonyms	16α,17α-Dihydroxyprogesterone acetophenide
Routes of administration	Intramuscular injection
ATC code	None
Identifiers
CAS Number	24356-94-3
PubChem CID	5284538
ChemSpider	4447595
ChEBI	CHEBI:49327
ECHA InfoCard	100.041.981
Chemical and physical data
Formula	C29H36O4
Molar mass	448.59 g/mol
3D model (JSmol)	Interactive image
SMILES O=C(C)[C@]25O[C@@](O[C@@H]5C[C@H]1[C@H]4[C@H](CC[C@@]12C)[C@@]3(/C(=C\C(=O)CC3)CC4)C)(c6ccccc6)C
InChI InChI=1S/C29H36O4/c1-18(30)29-25(32-28(4,33-29)19-8-6-5-7-9-19)17-24-22-11-10-20-16-21(31)12-14-26(20,2)23(22)13-15-27(24,29)3/h5-9,16,22-25H,10-15,17H2,1-4H3/t22-,23+,24+,25-,26+,27+,28-,29-/m1/s1 Key:AHBKIEXBQNRDNL-FVCOMRFXSA-N

Algestone acetophenide (USAN) (brand names Neolutin, Droxone, Deladroxone, Decadroxone, Dexadroxate, Bovitrol), also known as dihydroxyprogesterone acetophenide (DHPA), is a steroidal progestin of the 17α-hydroxyprogesterone group that is used as a contraceptive. It is marketed in combination with estradiol enanthate as a combined injectable contraceptive. The drug is the ketal formed between algestone and acetophenone. Algestone acetophenide is said to be both more potent and longer-acting than hydroxyprogesterone caproate. Unlike many other 17α-hydroxyprogesterone derivatives but similarly to hydroxyprogesterone caproate, algestone acetophenide is reported to possess no glucocorticoid activity.