Desmoglein 1

DSG1

Identifiers

DSG1, CDHF4, DG1, DSG, EPKHE, EPKHIA, PPKS1, SPPK1, desmoglein 1

External IDs

Genetically Related Diseases

Gene ontology
Molecular function	• calcium ion binding • gamma-catenin binding • metal ion binding • protein binding • toxic substance binding
Cellular component	• integral component of membrane • cytosol • lateral plasma membrane • membrane • cell-cell junction • plasma membrane • desmosome • cell junction • apical plasma membrane • cytoplasmic side of plasma membrane • extracellular exosome • extracellular matrix • cornified envelope • ficolin-1-rich granule membrane
Biological process	• calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules • single organismal cell-cell adhesion • maternal process involved in female pregnancy • response to progesterone • protein stabilization • cell adhesion • cell-cell junction assembly • homophilic cell adhesion via plasma membrane adhesion molecules • keratinization • neutrophil degranulation • cornification
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1828


13510


ENSG00000134760


ENSMUSG00000069441


Q02413


Q61495

RefSeq (mRNA)


NM_001942


NM_010079

RefSeq (protein)


NP_001933


NP_034209.2 NP_034209

Location (UCSC)

PubMed search

Desmoglein-1 is a protein that in humans is encoded by the DSG1 gene.

Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein-1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.