Pemphigus foliaceus

Pemphigus foliaceus
Classification and external resources
Specialty	dermatology
ICD-10	L10.2
DiseasesDB	31179
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Pemphigus foliaceus is an autoimmune blistering disease of the skin with characteristic lesions that are scaly, crusted erosions, often on an erythematous base. Mucosal involvement is absent even with widespread disease.

If there is an autoimmune IgG buildup in the epidermis, then nearly all of the antibodies are aimed against desmoglein 1. The effect of the antibodies and the immunological pathway is most likely either of three mechanisms:

Pemphigus is endemic in the rural areas of Brazil, especially along inland riverbeds.

The National Institute of Arthritis and Musculoskeletal and Skin Diseases describes it like this:

Normally, our immune system produces antibodies that attack viruses and harmful bacteria to keep us healthy. In people with pemphigus, however, the immune system mistakenly attacks the cells in the epidermis, or top layer of the skin, and the mucous membranes. The immune system produces antibodies against proteins in the skin known as desmogleins. These proteins form the glue that keeps skin cells attached and the skin intact. When desmogleins are attacked, skin cells separate from each other and fluid can collect between the layers of skin, forming blisters that do not heal. In some cases, these blisters can cover a large area of skin.

Pierre Louis Alphee Cazenave first described the disease in 1844.

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