Death receptor 5

TNFRSF10B
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1D0G, 1D4V, 1DU3, 1ZA3, 2H9G, 4I9X, 4N90, 4OD2, 3X3F
Identifiers
Aliases	TNFRSF10B, CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9, tumor necrosis factor receptor superfamily member 10b, TNF receptor superfamily member 10b
External IDs	HomoloGene: 117702 GeneCards: TNFRSF10B
Gene location (Human) Chr. Chromosome 8 (human) Band 8p21.3 Start 23,020,133 bp End 23,069,179 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • TRAIL binding • protein binding • tumor necrosis factor-activated receptor activity • receptor activity Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • cell surface • intracellular Biological process • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • activation of NF-kappaB-inducing kinase activity • response to endoplasmic reticulum stress • multicellular organism development • cell surface receptor signaling pathway • response to lipopolysaccharide • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • cellular response to mechanical stimulus • regulation of cell proliferation • immune response • positive regulation of I-kappaB kinase/NF-kappaB signaling • regulation of extrinsic apoptotic signaling pathway via death domain receptors • inflammatory response • activation of cysteine-type endopeptidase activity involved in apoptotic process • signal transduction • tumor necrosis factor-mediated signaling pathway • apoptotic process • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • leukocyte migration • extrinsic apoptotic signaling pathway via death domain receptors • regulation of apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8795	n/a
Ensembl	ENSG00000120889	n/a
UniProt	O14763	n/a
RefSeq (mRNA)	NM_003842 NM_147187	n/a
RefSeq (protein)	NP_003833 NP_671716	n/a
Location (UCSC)	Chr 8: 23.02 – 23.07 Mb	n/a
PubMed search		n/a

1D0G, 1D4V, 1DU3, 1ZA3, 2H9G, 4I9X, 4N90, 4OD2, 3X3F

8795

n/a

ENSG00000120889

n/a

O14763

n/a

NM_003842
NM_147187

n/a

NP_003833
NP_671716

n/a

Death receptor 5 (DR5), also known as TRAIL receptor 2 (TRAILR2) and tumor necrosis factor receptor superfamily member 10B (TNFRSF10B), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis.

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Mice have a homologous gene, tnfrsf10b, that has been essential in the elucidation of the function of this gene in humans. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.

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