David Lane (oncologist)

Professor Sir David Philip Lane FRCP FRCSEd FMedSci FRS FRSE (born 1952) is a British immunologist, molecular biologist and cancer researcher. He is currently Chief Scientist of the Agency for Science, Technology and Research (A*STAR) in Singapore, Scientific Director of Ludwig Cancer Research and Chairman of Chugai Pharmabody. He is best known for the discovery of p53, one of the most important tumour suppressor genes.

Sir David has published more than 350 research articles that have been citied over 39,000 times and is internationally recognised for his original discovery of the p53 protein SV40 T antigen complex and for his many subsequent contributions to the p53 field. The p53 gene is the most frequently altered gene in human cancer with more than half of all cancers having mutant p53. He is co-author with Ed Harlow of the most successful practical guide to the use of immunochemical methods. The "Antibodies" manual has sold over 40,000 copies.

Sir David completed his undergraduate and postgraduate degrees at University College, London where he studied auto-immunity under the supervision of Avrion Mitchison. He carried out Post Doctoral Research first at the Imperial Cancer Research Fund (ICRF) in London with Lionel Crawford and then at the Cold Spring Harbor Laboratory in New York with Joseph Sambrook. On returning to the UK, Sir David set up his own laboratory with Cancer Research Campaign (CRC) funding at Imperial College, London, then moving to the ICRF laboratories at Clare Hall before moving in 1990 to the University of Dundee to help establish the CRC laboratories there.

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