DUSP6

DUSP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HZM, 1MKP
Identifiers
Aliases	DUSP6, HH19, MKP3, PYST1, dual specificity phosphatase 6
External IDs	MGI: 1914853 HomoloGene: 55621 GeneCards: DUSP6
Gene ontology Molecular function • phosphoprotein phosphatase activity • phosphatase activity • hydrolase activity • MAP kinase tyrosine/serine/threonine phosphatase activity • protein tyrosine phosphatase activity • protein tyrosine/serine/threonine phosphatase activity Cellular component • nucleoplasm • cytosol • cytoplasm Biological process • negative regulation of protein phosphorylation • cell differentiation • positive regulation of cell death • response to organic cyclic compound • regulation of fibroblast growth factor receptor signaling pathway • inactivation of MAPK activity • protein dephosphorylation • response to organic substance • MAPK cascade • activation of MAPK activity • response to nitrosative stress • positive regulation of apoptotic process • negative regulation of ERK1 and ERK2 cascade • peptidyl-tyrosine dephosphorylation • response to growth factor • dorsal/ventral pattern formation • regulation of endodermal cell fate specification • response to drug • dephosphorylation • regulation of heart growth Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1848	67603
Ensembl	ENSG00000139318	ENSMUSG00000019960
UniProt	Q16828	Q9DBB1
RefSeq (mRNA)	NM_022652 NM_001946	NM_026268
RefSeq (protein)	NP_001937 NP_073143	NP_080544
Location (UCSC)	Chr 12: 89.35 – 89.35 Mb	Chr 10: 99.26 – 99.27 Mb
PubMed search

1HZM, 1MKP

1848

67603

ENSG00000139318

ENSMUSG00000019960

Q16828

Q9DBB1

NM_022652
NM_001946

NM_026268

NP_001937
NP_073143

NP_080544

Dual specificity phosphatase 6, also known as DUSP6, is an enzyme that in humans is encoded by the DUSP6 gene.

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas and, unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. Upregulation of MKP-3 has been shown to alleviate chronic postoperative pain.

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Wikipedia