DUSP16

DUSP16
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2VSW, 3TG3, 4YR8
Identifiers
Aliases	DUSP16, MKP-7, MKP7, dual specificity phosphatase 16
External IDs	MGI: 1917936 HomoloGene: 15604 GeneCards: DUSP16
Gene ontology Molecular function • protein tyrosine phosphatase activity • MAP kinase tyrosine/serine/threonine phosphatase activity • phosphoprotein phosphatase activity • hydrolase activity • protein tyrosine/serine/threonine phosphatase activity • phosphatase activity Cellular component • cytoplasm • cytosol • cytoplasmic vesicle • nucleus • nucleoplasm Biological process • inactivation of MAPK activity • MAPK export from nucleus • protein dephosphorylation • peptidyl-tyrosine dephosphorylation • MAPK phosphatase export from nucleus, leptomycin B sensitive • negative regulation of MAPK cascade • dephosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80824	70686
Ensembl	n/a	ENSMUSG00000030203
UniProt	Q9BY84	n/a
RefSeq (mRNA)	NM_030640	NM_001048054 NM_130447 NM_181320
RefSeq (protein)	NP_085143 NP_085143.1	n/a
Location (UCSC)	Chr 12: 12.47 – 12.56 Mb	Chr 6: 134.72 – 134.79 Mb
PubMed search

2VSW, 3TG3, 4YR8

80824

70686

n/a

ENSMUSG00000030203

Q9BY84

n/a

NM_030640

NM_001048054
NM_130447
NM_181320

NP_085143
NP_085143.1

n/a

Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.

The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs. MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.[supplied by OMIM]

DUSP16 has been shown to interact with MAPK14 and MAPK8IP1.

...
Wikipedia