DGCR8

DGCR8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X47, 2YT4, 3LE4, 5B16
Identifiers
Aliases	DGCR8, C22orf12, DGCRK6, Gy1, pasha, Pasha, DGCR8 microprocessor complex subunit, microprocessor complex subunit
External IDs	MGI: 2151114 HomoloGene: 11223 GeneCards: DGCR8
Gene ontology Molecular function • primary miRNA binding • ribonuclease III activity • double-stranded RNA binding • protein binding • heme binding • protein homodimerization activity • metal ion binding • RNA binding Cellular component • cytoplasm • microprocessor complex • nucleolus • nucleus • nucleoplasm Biological process • regulation of stem cell proliferation • primary miRNA processing • RNA phosphodiester bond hydrolysis, endonucleolytic • RNA phosphodiester bond hydrolysis • miRNA metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54487	94223
Ensembl	ENSG00000128191	n/a
UniProt	Q8WYQ5	Q9EQM6
RefSeq (mRNA)	NM_001190326 NM_022720	NM_033324
RefSeq (protein)	NP_001177255 NP_073557	NP_201581
Location (UCSC)	Chr 22: 20.08 – 20.11 Mb	Chr 16: 18.25 – 18.29 Mb
PubMed search

1X47, 2YT4, 3LE4, 5B16

54487

94223

ENSG00000128191

n/a

Q8WYQ5

Q9EQM6

NM_001190326
NM_022720

NM_033324

NP_001177255
NP_073557

NP_201581

The DGCR8 microprocessor complex subunit (DiGeorge syndrome chromosomal [or critical] region 8) is a protein that in humans is encoded by the DGCR8 gene. In other animals, particularly the common model organisms Drosophila melanogaster and Caenorhabditis elegans, the protein is known as Pasha (partner of Drosha). It is a required component of the RNA interference pathway.

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Wikipedia