Drosha

DROSHA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KHX, 5B16
Identifiers
Aliases	DROSHA, ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN, drosha ribonuclease III
External IDs	MGI: 1261425 HomoloGene: 8293 GeneCards: DROSHA
Gene ontology Molecular function • ribonuclease III activity • protein homodimerization activity • lipopolysaccharide binding • metal ion binding • endoribonuclease activity • protein binding • nuclease activity • endonuclease activity • hydrolase activity • RNA binding • DEAD/H-box RNA helicase binding • SMAD binding • R-SMAD binding • primary miRNA binding • double-stranded RNA binding Cellular component • nucleoplasm • microprocessor complex • nucleolus • nucleus • plasma membrane • focal adhesion Biological process • RNA processing • ribosome biogenesis • nucleic acid phosphodiester bond hydrolysis • rRNA catabolic process • positive regulation of gene expression • defense response to Gram-negative bacterium • regulation of miRNA metabolic process • primary miRNA processing • regulation of gene expression • defense response to Gram-positive bacterium • RNA phosphodiester bond hydrolysis, endonucleolytic • regulation of regulatory T cell differentiation • RNA phosphodiester bond hydrolysis • regulation of inflammatory response • miRNA metabolic process • gene silencing by RNA • production of siRNA involved in RNA interference • pre-miRNA processing Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	29102	14000
Ensembl	ENSG00000113360	ENSMUSG00000022191
UniProt	Q9NRR4	Q5HZJ0
RefSeq (mRNA)	NM_001100412 NM_013235	NM_001130149 NM_026799
RefSeq (protein)	NP_001093882 NP_037367	NP_001123621 NP_081075
Location (UCSC)	Chr 5: 31.4 – 31.53 Mb	Chr 15: 12.82 – 12.94 Mb
PubMed search

2KHX, 5B16

29102

14000

ENSG00000113360

ENSMUSG00000022191

Q9NRR4

Q5HZJ0

NM_001100412
NM_013235

NM_001130149
NM_026799

NP_001093882
NP_037367

NP_001123621
NP_081075

Drosha is a Class 2 ribonuclease III enzyme that in humans is encoded by the DROSHA (formerly RNASEN) gene.

Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells. The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus.

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Wikipedia