DCP2

DCP2
Identifiers
Aliases	DCP2, NUDT20, decapping mRNA 2
External IDs	MGI: 1917890 HomoloGene: 13968 GeneCards: DCP2
Gene ontology Molecular function • m7G(5')pppN diphosphatase activity • manganese ion binding • metal ion binding • protein binding • exoribonuclease activity, producing 5'-phosphomonoesters • RNA binding • hydrolase activity • 5'-3' exoribonuclease activity • telomerase RNA binding Cellular component • cytoplasm • RISC complex • cytosol • P-body • nucleoplasm • cell junction • nucleus Biological process • mRNA catabolic process • regulation of mRNA stability • deadenylation-dependent decapping of nuclear-transcribed mRNA • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay • histone mRNA catabolic process • RNA phosphodiester bond hydrolysis, exonucleolytic • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • negative regulation of telomere maintenance via telomerase • regulation of telomerase RNA localization to Cajal body Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	167227	70640
Ensembl	ENSG00000172795	ENSMUSG00000024472
UniProt	Q8IU60	Q9CYC6
RefSeq (mRNA)	NM_001242377 NM_152624	NM_027490
RefSeq (protein)	NP_001229306 NP_689837	NP_081766.1 NP_081766
Location (UCSC)	Chr 5: 112.98 – 113.02 Mb	Chr 18: 44.38 – 44.42 Mb
PubMed search

167227

70640

ENSG00000172795

ENSMUSG00000024472

Q8IU60

Q9CYC6

NM_001242377
NM_152624

NM_027490

NP_001229306
NP_689837

NP_081766.1
NP_081766

mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene.

DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]

DCP2 has been shown to interact with DCP1A and UPF1.

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Wikipedia