UPF1

UPF1

Protein UPF1 PDB 2gjk.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2GJK, 2GK6, 2GK7, 2IYK, 2WJV, 2WJY, 2XZO, 2XZP

Identifiers

UPF1, HNORF1, RENT1, pNORF1, smg-2, RNA helicase and ATPase

External IDs

MGI: 107995 HomoloGene: 2185 GeneCards: UPF1

Gene ontology
Molecular function	• nucleotide binding • DNA binding • telomeric DNA binding • zinc ion binding • chromatin binding • metal ion binding • protein binding • hydrolase activity • ATP binding • helicase activity • ATP-dependent RNA helicase activity • RNA binding
Cellular component	• cytosol • P-body • exon-exon junction complex • supraspliceosomal complex • nucleoplasm • chromatin • nuclear chromosome, telomeric region • cytoplasm • nucleus
Biological process	• regulation of translational termination • telomere maintenance via semi-conservative replication • positive regulation of mRNA catabolic process • mRNA export from nucleus • DNA replication • nuclear-transcribed mRNA catabolic process • cellular response to interleukin-1 • nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay • histone mRNA catabolic process • dosage compensation by inactivation of X chromosome • cellular response to lipopolysaccharide • 3'-UTR-mediated mRNA destabilization • DNA repair • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • regulation of telomere maintenance • cell cycle phase transition
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE UPF1 211168 s at fs.png

PBB GE UPF1 208947 s at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


5976


19704


ENSG00000005007


ENSMUSG00000058301


Q92900


Q9EPU0

RefSeq (mRNA)


NM_002911 NM_001297549


NM_001122829 NM_030680

RefSeq (protein)


NP_001284478 NP_002902 NP_001284478.1


NP_001116301 NP_109605

Location (UCSC)

Chr 19: 18.83 – 18.87 Mb

Chr 8: 70.33 – 70.35 Mb

PubMed search

2GJK, 2GK6, 2GK7, 2IYK, 2WJV, 2WJY, 2XZO, 2XZP

ENSG00000005007

ENSMUSG00000058301

NM_002911
NM_001297549

NM_001122829
NM_030680

NP_001284478
NP_002902
NP_001284478.1

NP_001116301
NP_109605

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Wikipedia

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