DAZAP1

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
2DGS, 2DH8

Identifiers

Aliases

DAZAP1, DAZ associated protein 1

External IDs

HomoloGene: 137331 GeneCards: DAZAP1

Gene ontology
Molecular function	• RNA stem-loop binding • nucleic acid binding • RNA binding
Cellular component	• nucleus • nucleoplasm • cytoplasm • cytosol
Biological process	• multicellular organism development • maternal placenta development • cell proliferation • cell differentiation • positive regulation of mRNA splicing, via spliceosome • spermatogenesis
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


26528


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Ensembl


ENSG00000071626


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UniProt


Q96EP5


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RefSeq (mRNA)


NM_018959 NM_170711 NM_001352033 NM_001352034 NM_001352035


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RefSeq (protein)


NP_061832 NP_733829 NP_001338962 NP_001338963 NP_001338964


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Location (UCSC)

Chr 19: 1.41 – 1.44 Mb

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PubMed search

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NM_018959
NM_170711
NM_001352033
NM_001352034
NM_001352035

n/a

NP_061832
NP_733829
NP_001338962
NP_001338963
NP_001338964

n/a

DAZ-associated protein 1 is a protein that in humans is encoded by the DAZAP1 gene.

In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ1 (Deleted in Azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes an RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene.

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Wikipedia