DAZL

DAZL
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2XS2, 2XS5, 2XS7, 2XSF
Identifiers
Aliases	DAZL, DAZH, DAZL1, DAZLA, SPGYLA, deleted in azoospermia like
External IDs	HomoloGene: 1034 GeneCards: DAZL
Gene ontology Molecular function • nucleic acid binding • protein binding • RNA binding • translation activator activity Cellular component • cytoplasm • nucleus Biological process • multicellular organism development • cell differentiation • regulation of translation • spermatogenesis • germ cell development • positive regulation of translational initiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1618	n/a
Ensembl	ENSG00000092345	n/a
UniProt	Q92904	n/a
RefSeq (mRNA)	NM_001351 NM_001190811	n/a
RefSeq (protein)	NP_001177740 NP_001342	n/a
Location (UCSC)	Chr 3: 16.59 – 16.67 Mb	n/a
PubMed search		n/a

2XS2, 2XS5, 2XS7, 2XSF

1618

n/a

ENSG00000092345

n/a

Q92904

n/a

NM_001351
NM_001190811

n/a

NP_001177740
NP_001342

n/a

Deleted in azoospermia-like is a protein that in humans is encoded by the DAZL gene.

The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males.

DAZL has been shown to interact with DAZ1.

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Wikipedia