Cristoforo Madruzzo ([kriˈstɔːforo maˈdruttso]) (July 5, 1512 – July 5, 1578) was an Italian Roman Catholic cardinal and statesman. His brother Eriprando was a mercenary captain who fought in the Italian Wars.
Madruzzo was born on July 5, 1512, at Calavino, into a noble family in Trento. He studied at Padua and Bologna, received in 1529 from his older brother a canonicate at Trento and the parish of Tirol near Meran, was in 1536 a Canon of Salzburg, in 1537 of Brixen, and in 1539 became Prince-Bishop of Trento. Being only a subdeacon at the time, he was promoted to the deaconship, priesthood and episcopate in 1542.
In January 1543, he was appointed administrator of the Bishopric of Brixen, and shortly afterwards, during the same year, he was raised to the dignity of a cardinal by Pope Paul III. Having resigned his bishopric at Trento in 1567 in favour of his nephew Ludovico, he spent the latter years of his life in Italy, and became Cardinal Bishop successively of Sabina, Palestrina, and Porto. A few years after his death, his remains were entombed in the family chapel, in the church of Sant'Onofrio, Rome.