Corticosteroid 11-beta-dehydrogenase isozyme 2

HSD11B2
Identifiers
Aliases	HSD11B2, AME, AME1, HSD11K, HSD2, SDR9C3, hydroxysteroid (11-beta) dehydrogenase 2, hydroxysteroid 11-beta dehydrogenase 2
External IDs	OMIM: 614232 MGI: 104720 HomoloGene: 20088 GeneCards: HSD11B2
Gene ontology Molecular function • NAD binding • steroid binding • oxidoreductase activity • 11-beta-hydroxysteroid dehydrogenase [NAD(P) activity] Cellular component • cytoplasm • endoplasmic reticulum membrane • intracellular membrane-bounded organelle • endoplasmic reticulum Biological process • response to hypoxia • glucocorticoid metabolic process • female pregnancy • response to steroid hormone • response to glucocorticoid • response to insulin • glucocorticoid biosynthetic process • regulation of blood volume by renal aldosterone • response to food • oxidation-reduction process • response to drug Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3291	15484
Ensembl	ENSG00000176387	ENSMUSG00000031891
UniProt	P80365	P51661
RefSeq (mRNA)	NM_000196	NM_008289
RefSeq (protein)	NP_000187	NP_032315.2 NP_032315
Location (UCSC)	Chr 16: 67.43 – 67.44 Mb	Chr 8: 105.52 – 105.52 Mb
PubMed search

3291

15484

ENSG00000176387

ENSMUSG00000031891

P80365

P51661

NM_000196

NM_008289

NP_000187

NP_032315.2
NP_032315

Corticosteroid 11-β-dehydrogenase isozyme 2 also known as 11-β-hydroxysteroid dehydrogenase 2 is an enzyme that in humans is encoded by the HSD11B2 gene.

Corticosteroid 11-β-dehydrogenase isozyme 2 is an NAD⁺-dependent enzyme expressed in aldosterone-selective epithelial tissues such as the kidney, colon, salivary and sweat glands. HSD211B2 expression is also found in the brainstem in a small, aldosterone-sensitive subset of neurons located in the nucleus of the solitary tract referred to as HSD2 neurons.

In these tissues, HSD11B2 oxidizes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. This protective mechanism is necessary because cortisol circulates at 100-1000-fold higher concentrations than aldosterone, and binds with equal affinity to the mineralocorticoid receptor, thereby out-competing aldosterone in cells that do not produce HSD11B2.

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