Corin

CORIN
Identifiers
Aliases	CORIN, ATC2, CRN, Lrp4, PEE5, TMPRSS10, corin, serine peptidase
External IDs	MGI: 1349451 HomoloGene: 4804 GeneCards: CORIN
Gene location (Human) Chr. Chromosome 4 (human) Band 4p12 Start 47,593,998 bp End 47,838,106 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band n/a Start 72,300,025 bp End 72,504,473 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptidase activity • hydrolase activity • serine-type peptidase activity • serine-type endopeptidase activity Cellular component • integral component of membrane • cell surface • integral component of plasma membrane • extracellular region • membrane • plasma • actin cytoskeleton • nuclear body Biological process • regulation of cardiac conduction • regulation of renal sodium excretion • proteolysis • regulation of blood pressure • regulation of systemic arterial blood pressure by atrial natriuretic peptide • peptide hormone processing • female pregnancy Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10699	53419
Ensembl	ENSG00000145244	ENSMUSG00000005220
UniProt	Q9Y5Q5	Q9Z319
RefSeq (mRNA)	NM_006587 NM_001278585 NM_001278586	NM_001122756 NM_016869
RefSeq (protein)	NP_001265514 NP_001265515 NP_006578	NP_001116228 NP_058565
Location (UCSC)	Chr 4: 47.59 – 47.84 Mb	Chr 4: 72.3 – 72.5 Mb
PubMed search

10699

53419

ENSG00000145244

ENSMUSG00000005220

Q9Y5Q5

Q9Z319

NM_006587
NM_001278585
NM_001278586

NM_001122756
NM_016869

NP_001265514
NP_001265515
NP_006578

NP_001116228
NP_058565

Corin, also called atrial natriuretic peptide-converting enzyme, is a protein that in humans is encoded by the CORIN gene.

The CORIN gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains.

Human corin, a polypeptide of 1042 amino acids, consists of an N-terminal cytoplasmic domain, a transmembrane domain and an extracellular region with two frizzled-like domains, eight LDL receptor-like domains, a scavenger receptor-like domain and a C-terminal trypsin-like serine protease domain. Corin is synthesized as a zymogen that is activated by PCSK6.

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