Compañía Panameña de Aviación, S.A., (: CPA) (commonly referred to simply as "Copa Airlines") is the flag carrier of Panama. It is headquartered in Panama City, Panama, with its main hub at . It operates more than 315 daily scheduled flights to 74 destinations in 31 countries around North, Central and South America, and the Caribbean. Copa is a subsidiary of Copa Holdings, S.A. as well as a member of the Star Alliance. The airline is also the main operator and owner of Colombian airline AeroRepública, currently known as Copa Airlines Colombia.

Copa was founded in 1947 as the national airline of Panama and it began domestic operations to three cities in Panama shortly afterwards. The airline then abandoned its domestic flights in 1980, in favor of international flights. In 1998, Copa formed a strategic partnership with Continental Airlines, adopting a new brand image and the OnePass frequent flyer program and later replaced by MileagePlus, which was replaced by ConnectMiles in July 2015.

As of 2013, Copa Airlines employed over 9,000 people, most of them residing in Panama and was one of the fastest growing and largest companies in the country. It is headed by Chief Executive Officer Pedro Heilbron.

The airline was established as Compañía Panameña de Aviación (hence the acronym COPA) on June 21, 1944, and started operations on August 15, 1947. It was founded by a group of prominent Panamanian investors with assistance from Pan American World Airways, who took a 32% stake. It began operating domestic flights with a small fleet of Douglas DC-3 aircraft. The airline started its first international flights in the early 1970s, with services to cities in Jamaica, Colombia, and Costa Rica.

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