Clock (gene)

CLOCK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4H10
Identifiers
Aliases	CLOCK, KAT13D, bHLHe8, clock circadian regulator
External IDs	OMIM: 601851 MGI: 99698 HomoloGene: 3603 GeneCards: CLOCK
Gene location (Human) Chr. Chromosome 4 (human) Band 4q12 Start 55,427,903 bp End 55,547,138 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 C3.3|5 40.63 cM Start 76,209,868 bp End 76,304,792 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • DNA binding • sequence-specific DNA binding • protein dimerization activity • core promoter binding • transcription factor activity, sequence-specific DNA binding • histone acetyltransferase activity • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription factor binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • E-box binding • core promoter sequence-specific DNA binding • protein binding • chromatin DNA binding • transferase activity, transferring acyl groups • RNA polymerase II transcription factor activity, sequence-specific DNA binding • RNA polymerase II distal enhancer sequence-specific DNA binding Cellular component • cytoplasm • chromatoid body • intracellular membrane-bounded organelle • transcription factor complex • chromosome • nucleoplasm • cell nucleus • cytosol Biological process • negative regulation of glucocorticoid receptor signaling pathway • positive regulation of inflammatory response • regulation of transcription, DNA-templated • photoperiodism • regulation of insulin secretion • rhythmic process • regulation of transcription from RNA polymerase II promoter • DNA damage checkpoint • regulation of type B pancreatic cell development • transcription from RNA polymerase II promoter • circadian regulation of gene expression • transcription, DNA-templated • positive regulation of transcription, DNA-templated • response to redox state • cellular response to DNA damage stimulus • positive regulation of NF-kappaB transcription factor activity • circadian rhythm • spermatogenesis • regulation of hair cycle • cellular response to ionizing radiation • negative regulation of transcription, DNA-templated • signal transduction • positive regulation of transcription from RNA polymerase II promoter • proteasome-mediated ubiquitin-dependent protein catabolic process • histone acetylation • protein acetylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9575	12753
Ensembl	ENSG00000134852	ENSMUSG00000029238
UniProt	O15516	O08785
RefSeq (mRNA)	NM_001267843 NM_004898	NM_007715 NM_001289826 NM_001305222
RefSeq (protein)	NP_001254772 NP_004889	NP_001276755 NP_001292151 NP_031741
Location (UCSC)	Chr 4: 55.43 – 55.55 Mb	Chr 5: 76.21 – 76.3 Mb
PubMed search

4H10

9575

12753

ENSG00000134852

ENSMUSG00000029238

O15516

O08785

NM_001267843
NM_004898

NM_007715
NM_001289826
NM_001305222

NP_001254772
NP_004889

NP_001276755
NP_001292151
NP_031741

Clock (Circadian Locomotor Output Cycles Kaput) is a gene encoding a basic helix-loop-helix-PAS transcription factor (CLOCK) that is believed to affect both the persistence and period of circadian rhythms.

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