Claud Hamilton, 1st Lord Paisley (Baptised 9 June 1546 – before 3 May 1621) was a Scottish politician. He was a younger son of James Hamilton, 2nd Earl of Arran. In 1553, he received the lands of the abbey of Paisley. As a hostage delivered to England by the Treaty of Berwick, he was said to be 14 years old in March 1560.
In 1568, Hamilton aided Mary, Queen of Scots, to escape from Loch Leven Castle, afterwards fighting for her at the Battle of Langside. His estates having been forfeited because of condemnation, Hamilton was concerned in the murder of the Regent James Stewart, 1st Earl of Moray in 1570, and also in that of the Regent Matthew Stewart, 4th Earl of Lennox in the following year; but in 1573 he recovered his estates.
Then in 1579 the privy council decided to arrest both him and his brother, Lord John Hamilton (c. 1535–1604) (afterwards 1st Marquess of Hamilton), to punish them for their past misdeeds; but the brothers escaped to the Kingdom of England, where Elizabeth I of England used them as pawns in the diplomatic game, and later Claud lived for a short time in France.
Returning to Scotland in 1586 and mixing again in politics, Hamilton sought to reconcile James VI of Scotland with his mother; he was in communication with Philip II of Spain in the interests of Mary and the Roman Catholic religion, and neither the failure of Anthony Babington's plot nor even the defeat of the Spanish Armada put an end to these intrigues. In 1589 some of his letters were seized and he suffered a short imprisonment, after which he practically disappeared from public life.