Citrate synthase
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| Aliases | CS, citrate synthase | ||||||||||||||||
| External IDs | MGI: 88529 HomoloGene: 56073 GeneCards: CS | ||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||
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| Location (UCSC) | Chr 12: 56.27 – 56.3 Mb | Chr 10: 128.34 – 128.36 Mb | |||||||||||||||
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| Citrate (Si)-synthase | |||||||||
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| EC number | 2.3.3.1 | ||||||||
| CAS number | 9027-96-7 | ||||||||
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| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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| PMC | articles |
| PubMed | articles |
| NCBI | proteins |
The enzyme citrate synthase [E.C. 2.3.3.1 (previously 4.1.3.7)] exists in nearly all living cells and stands as a pace-making enzyme in the first step of the citric acid cycle (or Krebs cycle). Citrate synthase is localized within eukaryotic cells in the , but is encoded by nuclear DNA rather than mitochondrial. It is synthesized using cytoplasmic ribosomes, then transported into the mitochondrial matrix. Citrate synthase is commonly used as a quantitative enzyme marker for the presence of intact .
Citrate synthase catalyzes the condensation reaction of the two-carbon acetate residue from acetyl coenzyme A and a molecule of four-carbon oxaloacetate to form the six-carbon citrate:
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Wikipedia