Chemerin

RARRES2
Identifiers
Aliases	RARRES2, HP10433, TIG2, Chemerin, retinoic acid receptor responder 2
External IDs	MGI: 1918910 HomoloGene: 2167 GeneCards: RARRES2
Gene ontology Molecular function • protein binding • receptor binding Cellular component • extracellular matrix • extracellular exosome • platelet dense granule lumen • extracellular region • extracellular space Biological process • in utero embryonic development • brown fat cell differentiation • embryonic digestive tract development • positive regulation of macrophage chemotaxis • chemotaxis • retinoid metabolic process • cell differentiation • inflammatory response • positive regulation of protein phosphorylation • positive regulation of fat cell differentiation • regulation of lipid catabolic process • positive regulation of chemotaxis • positive regulation of glucose import in response to insulin stimulus • platelet degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5919	71660
Ensembl	ENSG00000106538	ENSMUSG00000009281
UniProt	Q99969	Q9DD06
RefSeq (mRNA)	NM_002889	NM_027852 NM_001347167 NM_001347168
RefSeq (protein)	NP_002880 NP_002880.1	NP_082128.1 NP_001334096 NP_001334097 NP_082128
Location (UCSC)	Chr 7: 150.34 – 150.34 Mb	Chr 6: 48.57 – 48.57 Mb
PubMed search

5919

71660

ENSG00000106538

ENSMUSG00000009281

Q99969

Q9DD06

NM_002889

NM_027852
NM_001347167
NM_001347168

NP_002880
NP_002880.1

NP_082128.1
NP_001334096
NP_001334097
NP_082128

Chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), tazarotene-induced gene 2 protein (TIG2), or RAR-responsive protein TIG2 is a protein that in humans is encoded by the RARRES2 gene.

Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2 (this gene), and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES2 is thought to act as a cell surface receptor.

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Wikipedia