Charles Louis Huguet, marquis de Sémonville (9 March 1759 – 11 August 1839) was a French diplomat and politician. He was made a count of the First French Empire in 1808, and marquis in 1819.
Born in Paris on as the son of one of the royal secretaries, he became Minister and Envoy Extraordinary of France to the Republic of Genoa in 1790-1791, he was instructed by Charles François Dumouriez to go to Turin and attempt to break off the alliance between Victor Amadeus III of Sardinia and the Habsburg Monarchy, but was not permitted to cross the Sardinian frontier. Between 1792 and 1796, he was nominal ambassador to the Ottoman Empire (he never occupied the post).
In 1793 he had started with Hugues-Bernard Maret for Italy where they had missions to the Grand Duchy of Tuscany and the Kingdom of Naples respectively, when the two envoys were kidnapped by Austrian orders in the Valtellina. They remained in a Tyrol prison until December 1795, when there was an exchange of prisoners on the release of Madame Royale, daughter of the executed King Louis XVI, from the Temple prison.