The Central District of Khusf County (Persian: بخش مرکزی شهرستان خوسف) is a district (bakhsh) in Khusf County, South Khorasan Province, Iran. At the 2006 census, its population was 12,605, in 3,632 families. The District has two cities: Khusf and Mohammadshahr. The District has two rural districts (dehestan): Khusf Rural District and Khur Rural District.