Called Mes-kwah-wa-se-pe or "old redwood creek" by Native Americans, Cedar Creek is the largest tributary of the St. Joseph River, draining 174,780 acres (707.3 km2) in northeastern Indiana. It is 31.9 miles (51.3 km) long, rising in northwestern DeKalb County and joining the St. Joseph just below the Cedarville Dam in Allen County.
Upper Cedar Creek originated as an ice-marginal channel at the western edge of the Erie Lobe of the Wisconsin Glacier and formed a single stream with the southwest-flowing Eel River which connected to the Wabash River. Lower Cedar Creek was a tributary of the ancestral Eel, carrying glacial meltwater under the ice through a tunnel valley known today as Cedar Creek Canyon. Blockage of the Eel's channel by outwash from the canyon and a decline in the volume of meltwater caused lower Cedar Creek to reverse its flow. In so doing, it captured the flow of the upper Eel, a classic example of stream piracy that shifted Cedar Creek's drainage (about 175,000 acres) from the Eel-Wabash system to that of the St. Joseph-Maumee.
Once a meandering stream, upper Cedar Creek was channelized (straightened and deepened) in the early 20th century for agricultural and urban drainage, which has increased the watershed's vulnerability to erosion and contaminated runoff. Once home to 27 species of freshwater mussel, Cedar Creek has experienced a drastic decline in mussel population since the 1980s.