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Cdt1

CDT1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CDT1, DUP, RIS2, chromatin licensing and DNA replication factor 1
External IDs MGI: 1914427 HomoloGene: 32650 GeneCards: CDT1
RNA expression pattern
PBB GE CDT1 209832 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030928

NM_026014

RefSeq (protein)

NP_112190

NP_112190
NP_080290

Location (UCSC) Chr 16: 88.8 – 88.81 Mb Chr 8: 122.57 – 122.57 Mb
PubMed search

2LE8, 2WVR

NM_030928

NM_026014

NP_112190

NP_112190
NP_080290

DNA replication factor Cdt1 is a protein that in humans is encoded by the CDT1 gene.

The protein encoded by this gene is a key licensing factor which, along with the protein Cdc6, functions to license DNA by forming the pre-replication complex (pre-RC). Its activity during the cell cycle is tightly regulated by its association with the protein geminin, which both inhibits Cdt1 activity during S phase in order to prevent re-replication of DNA and prevents it from ubiquitination and subsequent proteolysis.


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Wikipedia

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