Caveolin 2

CAV2
Identifiers
Aliases	CAV2, CAV, caveolin 2
External IDs	MGI: 107571 HomoloGene: 942 GeneCards: CAV2
Gene location (Human) Chr. Chromosome 7 (human) Band 7q31.2 Start 116,287,380 bp End 116,508,541 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 A2 Start 17,281,185 bp End 17,289,115 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding, bridging • protein homodimerization activity • scaffold protein binding • protein binding • protein heterodimerization activity • protein complex scaffold activity • D1 dopamine receptor binding • protein kinase binding Cellular component • cytoplasm • Golgi apparatus • membrane • focal adhesion • extrinsic component of cytoplasmic side of plasma membrane • Golgi membrane • plasma membrane • integral component of plasma membrane • intracellular • transport vesicle • acrosomal membrane • protein complex • perinuclear region of cytoplasm • caveola • membrane raft • cytoplasmic vesicle • nucleus Biological process • insulin receptor signaling pathway • positive regulation by host of viral release from host cell • positive regulation of endothelial cell proliferation • caveola assembly • vesicle organization • mitochondrion organization • negative regulation of transforming growth factor beta receptor signaling pathway • positive regulation of dopamine receptor signaling pathway • endoplasmic reticulum organization • negative regulation of endothelial cell proliferation • vesicle docking • positive regulation of GTPase activity • positive regulation by host of viral process • skeletal muscle fiber development • protein oligomerization • receptor-mediated endocytosis of virus by host cell • vesicle fusion • positive regulation of MAPK cascade • regulation of mitotic nuclear division • negative regulation of cell proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	858	12390
Ensembl	ENSG00000105971	ENSMUSG00000000058
UniProt	P51636	Q9WVC3
RefSeq (mRNA)	NM_001206747 NM_001206748 NM_001233 NM_198212	NM_001277756 NM_016900
RefSeq (protein)	NP_001193676 NP_001193677 NP_001224 NP_937855	NP_001264685 NP_058596
Location (UCSC)	Chr 7: 116.29 – 116.51 Mb	Chr 7: 17.28 – 17.29 Mb
PubMed search

858

12390

ENSG00000105971

ENSMUSG00000000058

P51636

Q9WVC3

NM_001206747
NM_001206748
NM_001233
NM_198212

NM_001277756
NM_016900

NP_001193676
NP_001193677
NP_001224
NP_937855

NP_001264685
NP_058596

Caveolin-2 is a protein that in humans is encoded by the CAV2 gene.

The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Two transcript variants encoding distinct isoforms have been identified for this gene. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by one transcript.

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