Caveolin 1

CAV1
Identifiers
Aliases	CAV1, BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21, Caveolin 1
External IDs	MGI: 102709 HomoloGene: 1330 GeneCards: CAV1
Gene ontology Molecular function • protein binding, bridging • ion channel binding • structural molecule activity • receptor binding • nitric-oxide synthase binding • patched binding • enzyme binding • peptidase activator activity • Rac GTPase binding • protein binding • protein complex scaffold • protein kinase binding • ATPase binding • cholesterol binding • inward rectifier potassium channel inhibitor activity • identical protein binding • protein heterodimerization activity Cellular component • endocytic vesicle membrane • endosome • membrane • focal adhesion • VCP-NPL4-UFD1 AAA ATPase complex • perinuclear region of cytoplasm • caveola • cilium • apical plasma membrane • endoplasmic reticulum • membrane raft • integral component of membrane • Golgi apparatus • early endosome membrane • plasma membrane • intracellular • protein complex • cell cortex • endoplasmic reticulum membrane • Golgi membrane • integral component of plasma membrane • acrosomal membrane • basolateral plasma membrane • cytoplasmic vesicle • lipid particle Biological process • caveolin-mediated endocytosis • positive regulation of calcium ion transport into cytosol • vasoconstriction • response to progesterone • inactivation of MAPK activity • negative regulation of protein binding • regulation of peptidase activity • protein localization to plasma membrane raft • mammary gland development • vasculogenesis • negative regulation of pinocytosis • response to ischemia • angiogenesis • apoptotic signaling pathway • positive regulation of extrinsic apoptotic signaling pathway • cholesterol homeostasis • triglyceride metabolic process • negative regulation of canonical Wnt signaling pathway • calcium ion transport • negative regulation of cell proliferation • cellular response to transforming growth factor beta stimulus • positive regulation of toll-like receptor 3 signaling pathway • regulation of cytosolic calcium ion concentration • regulation of smooth muscle contraction • vesicle organization • negative regulation of tyrosine phosphorylation of Stat5 protein • negative regulation of peptidyl-tyrosine autophosphorylation • regulation of inward rectifier potassium channel activity • regulation of cardiac muscle cell action potential involved in regulation of contraction • negative regulation of transforming growth factor beta receptor signaling pathway • protein localization to basolateral plasma membrane • receptor internalization involved in canonical Wnt signaling pathway • regulation of membrane repolarization during action potential • positive regulation of peptidyl-serine phosphorylation • negative regulation of protein tyrosine kinase activity • regulation of entry of bacterium into host cell • negative regulation of MAP kinase activity • positive regulation of vasoconstriction • negative regulation of potassium ion transmembrane transport • lactation • receptor-mediated endocytosis of virus by host cell • regulation of blood coagulation • regulation of ventricular cardiac muscle cell action potential • protein homooligomerization • viral process • positive regulation of intrinsic apoptotic signaling pathway • negative regulation of JAK-STAT cascade • mammary gland involution • calcium ion homeostasis • negative regulation of necroptotic process • regulation of the force of heart contraction • lipid storage • nitric oxide homeostasis • membrane depolarization • negative regulation of cytokine-mediated signaling pathway • cellular calcium ion homeostasis • negative regulation of transcription from RNA polymerase II promoter • response to estrogen • response to calcium ion • regulation of fatty acid metabolic process • cellular response to exogenous dsRNA • negative regulation of MAPK cascade • regulation of ruffle assembly • positive regulation of protein binding • positive regulation of protein ubiquitination • negative regulation of anoikis • leukocyte migration • protein localization • positive regulation of cell adhesion molecule production • response to hypoxia • negative regulation of nitric-oxide synthase activity • response to bacterium • caveola assembly • cellular response to hyperoxia • cholesterol transport • cellular response to starvation • T cell costimulation • regulation of nitric-oxide synthase activity • receptor internalization • MAPK cascade • positive regulation of peptidase activity • positive regulation of ER-associated ubiquitin-dependent protein catabolic process • negative regulation of endothelial cell proliferation • negative regulation of BMP signaling pathway • negative regulation of protein ubiquitination • cellular response to peptide hormone stimulus • positive regulation of gene expression • negative regulation of nitric oxide biosynthetic process • angiotensin-activated signaling pathway involved in heart process • protein oligomerization • negative regulation of peptidyl-serine phosphorylation • posttranscriptional regulation of gene expression • positive regulation of gap junction assembly • maintenance of protein location in cell • negative regulation of signal transduction • regulation of the force of heart contraction by chemical signal • regulation of cell communication by electrical coupling involved in cardiac conduction • regulation of heart rate by cardiac conduction • negative regulation of epithelial cell differentiation • skeletal muscle tissue development • beta-catenin destruction complex disassembly • positive regulation of catalytic activity • positive regulation of canonical Wnt signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	857	12389
Ensembl	ENSG00000105974	ENSMUSG00000007655
UniProt	Q03135	P49817
RefSeq (mRNA)	NM_001753 NM_001172895 NM_001172896 NM_001172897	NM_001243064 NM_007616
RefSeq (protein)	NP_001166366 NP_001166367 NP_001166368 NP_001744	NP_001229993.1 NP_031642.1 NP_001229993 NP_031642
Location (UCSC)	Chr 7: 116.52 – 116.56 Mb	Chr 6: 17.31 – 17.34 Mb
PubMed search

857

12389

ENSG00000105974

ENSMUSG00000007655

Q03135

P49817

NM_001753
NM_001172895
NM_001172896
NM_001172897

NM_001243064
NM_007616

NP_001166366
NP_001166367
NP_001166368
NP_001744

NP_001229993.1
NP_031642.1
NP_001229993
NP_031642

Caveolin-1 is a protein that in humans is encoded by the CAV1 gene.

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Wikipedia