Cathepsin E

CTSE
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TZS
Identifiers
Aliases	CTSE, Ctse, A430072O03Rik, C920004C08Rik, CE, CatE, cathepsin E
External IDs	MGI: 107361 HomoloGene: 37551 GeneCards: CTSE
Gene ontology Molecular function • peptidase activity • hydrolase activity • protein homodimerization activity • aspartic-type endopeptidase activity Cellular component • endosome • extracellular exosome Biological process • digestion • protein autoprocessing • protein catabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class II • proteolysis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1510	13034
Ensembl	ENSG00000196188	ENSMUSG00000004552
UniProt	P14091	P70269
RefSeq (mRNA)	NM_001910 NM_148964 NM_001317331	NM_007799
RefSeq (protein)	NP_001304260 NP_001901 NP_683865	NP_031825.2 NP_031825
Location (UCSC)	Chr 1: 206.01 – 206.02 Mb	Chr 1: 131.64 – 131.68 Mb
PubMed search

1TZS

1510

13034

ENSG00000196188

ENSMUSG00000004552

P14091

P70269

NM_001910
NM_148964
NM_001317331

NM_007799

NP_001304260
NP_001901
NP_683865

NP_031825.2
NP_031825

Cathepsin E is an enzyme that in humans is encoded by the CTSE gene.

Cathepsin E is a protease found in animals, as well as various other organisms, that belongs to the aspartic protease group. In humans it is encoded by the CTSE gene located at 1q32 on chromosome 1. It is an intracellular non-lysosomal glycoprotein that is mainly found in the skin and in immune cells. The protein is an aspartyl protease that functions as a disulfide-linked homodimer, and has an oligosaccharide chain of the high-mannose type. It is a member of the peptidase A1 family, and therefore observes specificity similar to that of Pepsin A and Cathepsin D. Cathepsin E is an intracellular enzyme and does not appear to be involved in dietary protein digestion. It is found at highest abundance on the stomach’s epithelial mucus producing cell surfaces. It is the first aspartic protease present in the fetal stomach and is found in more than half of gastric cancers, leading to it appearing to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene.

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