Cathepsin D

CTSD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LYA, 1LYB, 1LYW, 4OBZ, 4OC6, 4OD9
Identifiers
Aliases	CTSD, CLN10, CPSD, HEL-S-130P, cathepsin D
External IDs	MGI: 88562 HomoloGene: 55616 GeneCards: CTSD
Gene ontology Molecular function • peptidase activity • hydrolase activity • protein binding • serine-type endopeptidase activity • cysteine-type endopeptidase activity • aspartic-type endopeptidase activity Cellular component • lysosomal lumen • extracellular exosome • membrane raft • extracellular matrix • lysosome • melanosome • extracellular region • extracellular space • specific granule lumen • tertiary granule lumen • ficolin-1-rich granule lumen Biological process • protein catabolic process • autophagy • collagen catabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class II • proteolysis • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1509	13033
Ensembl	ENSG00000117984	ENSMUSG00000007891
UniProt	P07339	P18242
RefSeq (mRNA)	NM_001909	NM_009983
RefSeq (protein)	NP_001900	NP_034113.1 NP_034113
Location (UCSC)	Chr 11: 1.75 – 1.76 Mb	Chr 7: 142.38 – 142.39 Mb
PubMed search

1LYA, 1LYB, 1LYW, 4OBZ, 4OC6, 4OD9

1509

13033

ENSG00000117984

ENSMUSG00000007891

P07339

P18242

NM_001909

NM_009983

NP_001900

NP_034113.1
NP_034113

Cathepsin D is a protein that in humans is encoded by the CTSD gene. This gene encodes a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. Cathepsin D is an aspartic endo-protease that is ubiquitously distributed in lysosomes. The main function of cathepsin D is to degrade proteins and activate precursors of bioactive proteins in pre-lysosomal compartments. This proteinase, which is a member of the peptidase A1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of the CTSD gene is initiated from several sites, including one that is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. Homozygous deletion of the CTSD gene leads to early lethality in the post-natal phase. Deficiency of CTSD gene has been reported an underlying cause of neuronal ceroid lipofuscinosis (NCL).

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Wikipedia