Cartilage oligomeric matrix protein

COMP

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3FBY

Identifiers

Aliases

COMP, EDM1, EPD1, MED, PSACH, THBS5, cartilage oligomeric matrix protein, TSP5

External IDs

OMIM: 600310 MGI: 88469 HomoloGene: 74 GeneCards: COMP

Gene ontology
Molecular function	• protease binding • calcium ion binding • heparan sulfate proteoglycan binding • heparin binding • extracellular matrix structural constituent • protein binding • collagen binding
Cellular component	• extracellular region • proteinaceous extracellular matrix • extracellular matrix • extracellular exosome • extracellular space
Biological process	• animal organ morphogenesis • growth plate cartilage development • skeletal system development • cell adhesion • extracellular matrix organization • negative regulation of apoptotic process • limb development • apoptotic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1311


12845

Ensembl


ENSG00000105664


ENSMUSG00000031849

UniProt


P49747


Q9R0G6

RefSeq (mRNA)


NM_000095


NM_016685

RefSeq (protein)


NP_000086


NP_057894

Location (UCSC)

Chr 19: 18.78 – 18.79 Mb

Chr 8: 70.37 – 70.38 Mb

PubMed search

Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily present in cartilage. In humans it is encoded by the COMP gene.

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfide bonds. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).

...
Wikipedia