Cannabinoid receptor 2

CNR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KI9
Identifiers
Aliases	CNR2, CB-2, CB2, CX5, Cannabinoid receptor type 2, cannabinoid receptor 2
External IDs	MGI: 104650 HomoloGene: 1389 GeneCards: CNR2
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • cannabinoid receptor activity Cellular component • integral component of membrane • perikaryon • cell projection • membrane • extrinsic component of cytoplasmic side of plasma membrane • plasma membrane • integral component of plasma membrane • neuronal cell body • dendrite • neuron projection Biological process • G-protein coupled receptor signaling pathway • negative regulation of nitric-oxide synthase activity • negative regulation of mast cell activation • cannabinoid signaling pathway • response to amphetamine • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • negative regulation of action potential • response to lipopolysaccharide • negative regulation of synaptic transmission, GABAergic • immune response • sensory perception of pain • inflammatory response • negative regulation of inflammatory response • signal transduction • leukocyte chemotaxis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1269	12802
Ensembl	ENSG00000188822	ENSMUSG00000062585
UniProt	P34972	P47936
RefSeq (mRNA)	NM_001841	NM_009924 NM_001305278
RefSeq (protein)	NP_001832	NP_001292207 NP_034054
Location (UCSC)	Chr 1: 23.87 – 23.91 Mb	Chr 4: 135.9 – 135.92 Mb
PubMed search

2KI9

1269

12802

ENSG00000188822

ENSMUSG00000062585

P34972

P47936

NM_001841

NM_009924
NM_001305278

NP_001832

NP_001292207
NP_034054

The cannabinoid receptor type 2, abbreviated as CB₂, is a G protein-coupled receptor from the cannabinoid receptor family that in humans is encoded by the CNR2 gene. It is closely related to the cannabinoid receptor type 1, which is largely responsible for the efficacy of endocannabinoid-mediated presynaptic-inhibition, the psychoactive properties of tetrahydrocannabinol, the active agent in cannabis, and other (plant cannabinoids). The principal endogenous ligand for the CB₂ receptor is 2-arachidonoylglycerol (2-AG).

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Wikipedia