"Can't Knock the Hustle" is the third single from rapper Jay-Z's debut album Reasonable Doubt. The song features a beat produced by Knobody, co-produced by Sean C and Dahoud Darien, as well as a chorus sung by Mary J. Blige.

"Can't Knock the Hustle" marked Knobody's first foray into outside production after the rap group he was in disbanded.Knobody had been very pleased with the last track he had produced for the band and, together with Sean C, had taken it to the nearby home of Roc-A-Fella's Damon Dash. Dash then showed it to Jay-Z, who was suitably impressed and encouraged the young producer to contribute beats.Knobody then gave Jay-Z the backing track to what would become "Can't Knock The Hustle". The rapper then recorded the track.

Combat Jack spoke to Complex about the record. Saying "This song was an effing pain in the ass, as it was the beginning of the end of my run with Roc-A-Fella. Because Dame 'dated' Mary J. Blige briefly, right before she blew up, she did him a solid and dropped her cameo on 'Can't Knock The Hustle.' This was supposed to be the first official single, and like B.I.G., Mary J. Blige was running this 'Queen of R&B and Hip Hop' shit. And like 'Brooklyn's Finest,' the label did not want to have her associated with some unknown 'Jay-Z' rapper dude. In response to my request, MCA/Universal records flat-out ordered Dame to remove any and all types of Mary references from Reasonable Doubt. This was bad, mainly because Dame had spent mad money advertising how the song featured Mary, and there was even a full-page ad out in The Source! "I decided to pull a favor from one of my colleagues that was a top exec at Universal. Granting me a solid, he said they'd allow for Mary to remain on the album—only no singles, no videos, and no advertising. Dame was pissed, and had me set up a conference call with said Universal connect. On the call, as my connect was explaining to Dame why Mary could not appear on a single, Dame lost it and asked dude if he owned Universal. When dude said he didn't, Dame laid into him (and me) about how I had him dealing with 'peons.' My heart dropped and I immediately dropped Dame from the call. Pissed that I just wasted a major favor, and having dude now totally done with me, I continued to apologize to my connect for Dame's behavior. I damn near had to suck him off to keep Mary J. Blige on the album. Pause. Afterwards, I had a major argument with Dame, how he could go ahead and burn his bridges, but how there was no way in hell I'd allow him to burn any more of mine. You could say that that's when we started hating each other. Switching to plan B, Dame had to replace Mary's vocals with Me'lissa Morgan's for the single. Me'lissa was also featured in the video. Dame did keep the Mary version on the album. It wasn't Mary's fault, but there was mad drama behind this song."

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