Calretinin

CALB2
Identifiers
Aliases	CALB2, CAB29, CAL2, CR, calbindin 2
External IDs	OMIM: 114051 MGI: 101914 HomoloGene: 1318 GeneCards: CALB2
Gene ontology Molecular function • calcium ion binding • metal ion binding Cellular component • neuron projection • gap junction • terminal bouton • synapse • nucleus • cytoplasm • cytosol Biological process • regulation of cytosolic calcium ion concentration Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	794	12308
Ensembl	n/a	ENSMUSG00000003657
UniProt	P22676	Q08331
RefSeq (mRNA)	NM_001740 NM_007087 NM_007088	NM_007586
RefSeq (protein)	NP_001731 NP_009019	NP_031612.1 NP_031612
Location (UCSC)	Chr 16: 71.36 – 71.39 Mb	Chr 8: 110.14 – 110.17 Mb
PubMed search

794

12308

n/a

ENSMUSG00000003657

P22676

Q08331

NM_001740
NM_007087
NM_007088

NM_007586

NP_001731
NP_009019

NP_031612.1
NP_031612

Calretinin also known as 29 kDa calbindin is a calcium-binding protein involved in calcium signaling. In humans, the calretinin protein is encoded by the CALB2 gene.

This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering.

Calretinin is abundantly expressed in neurons including retina (which gave it the name) and cortical interneurons. Expression was found in different neurons than that of the similar vitamin D-dependent calcium-binding protein, calbindin-28kDa.

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Wikipedia