Troponin C

Troponin C is a part of the troponin complex. It contains four calcium-binding EF hands, although different isoforms may have fewer than four functional calcium-binding subdomains. It is a component of thin filaments (along with actin and tropomyosin). It contains an N lobe and a C lobe. The C lobe serves a structural purpose and binds to the N domain of troponin I (TnI). The C lobe can bind either Ca²⁺ or Mg²⁺. The N lobe, which binds only Ca²⁺, is the regulatory lobe and binds to the C domain of troponin I after calcium binding.

The tissue specific subtypes are:

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