Calgary Centre (French: Calgary-Centre; formerly known as Calgary South Centre) is a federal electoral district in Alberta, Canada, that has been represented in the House of Commons of Canada since 1968. The riding consists of many young adults who have a relatively high average household income and education level. As the riding encompasses the downtown core and large swaths of apartment blocks in the communities west and south of downtown, Calgary Centre has a low home ownership rate compared to the rest of Canada.

The original Calgary Centre was created in 1966 from parts of the former electoral districts of Calgary North and Calgary South. This riding was abolished in the 2003 Representation Order when parts of it went to the neighbouring electoral districts of Calgary North Centre and Calgary West and to Calgary South Centre. The latter was renamed Calgary Centre in 2004. When it was created in 2003 (as Calgary South Centre), it included 70,972 people from the abolished district of Calgary Centre, 38,889 people from Calgary West and 7,578 from Calgary Southwest.

The riding was notable at the 2000 federal election when residents elected former Prime Minister Joe Clark, representing the Progressive Conservatives, making the riding one of the few areas in Alberta that did not elect a candidate from the Canadian Alliance.

This riding lost territory to Calgary Signal Hill and gained territory from Calgary East during the 2012 electoral redistribution.

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