Calcium-sensing receptor

CASR

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
5FBH, 5FBK

Identifiers

Aliases

CASR, CAR, EIG8, FHH, FIH, GPRC2A, HHC, HHC1, HYPOC1, NSHPT, PCAR1, calcium sensing receptor

External IDs

OMIM: 601199 MGI: 1351351 HomoloGene: 332 GeneCards: CASR

Targeted by Drug

spermine, NPS-2143, cinacalcet, L-Tryptophan

Gene ontology
Molecular function	• protein binding • signal transducer activity • phosphatidylinositol phospholipase C activity • G-protein coupled receptor activity • calcium ion binding • amino acid binding • protein homodimerization activity • metal ion binding
Cellular component	• integral component of membrane • plasma membrane • membrane • integral component of plasma membrane
Biological process	• chemosensory behavior • calcium ion import • anatomical structure morphogenesis • ossification • signal transduction • detection of calcium ion • cellular calcium ion homeostasis • G-protein coupled receptor signaling pathway
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


846


12374

Ensembl


ENSG00000036828


ENSMUSG00000051980

UniProt


P41180


Q9QY96

RefSeq (mRNA)


NM_000388 NM_001178065


NM_013803

RefSeq (protein)


NP_000379 NP_001171536


NP_038831.2 NP_038831

Location (UCSC)

Chr 3: 122.18 – 122.29 Mb

Chr 16: 36.49 – 36.56 Mb

PubMed search

NM_000388
NM_001178065

NM_013803

NP_000379
NP_001171536

NP_038831.2
NP_038831

The calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ion. It is primarily expressed in the parathyroid gland and the renal tubules of the kidney. In the parathyroid gland, the calcium-sensing receptor controls calcium homeostasis by regulating the release of parathyroid hormone (PTH). In the kidney it has an inhibitory effect on the reabsorbtion of calcium, potassium, sodium, and water depending on which segment of the tubule is being activated.

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