CYP4F12

CYP4F12
Identifiers
Aliases	CYP4F12, CYPIVF12, F22329_1, cytochrome P450 family 4 subfamily F member 12
External IDs	MGI: 1927669 HomoloGene: 81872 GeneCards: CYP4F12
Gene ontology Molecular function • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • alkane 1-monooxygenase activity • monooxygenase activity • aromatase activity • oxidoreductase activity • leukotriene-B4 20-monooxygenase activity • heme binding • metal ion binding • iron ion binding • arachidonic acid epoxygenase activity • oxygen binding Cellular component • endoplasmic reticulum • apical plasma membrane • cytoplasm • organelle membrane • integral component of membrane • membrane • endoplasmic reticulum membrane • intracellular membrane-bounded organelle Biological process • arachidonic acid metabolic process • pressure natriuresis • vitamin E metabolic process • epoxygenase P450 pathway • long-chain fatty acid metabolic process • drug metabolic process • leukotriene B4 catabolic process • very long-chain fatty acid metabolic process • sodium ion homeostasis • renal water homeostasis • oxidation-reduction process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	66002	64385
Ensembl	ENSG00000186204	ENSMUSG00000024292
UniProt	Q9HCS2	Q9EP75
RefSeq (mRNA)	NM_023944	NM_001204333 NM_001204334 NM_001204335 NM_001204336 NM_022434
RefSeq (protein)	NP_076433	NP_001191262 NP_001191263 NP_001191264 NP_001191265 NP_071879
Location (UCSC)	Chr 19: 15.67 – 15.7 Mb	Chr 17: 32.91 – 32.92 Mb
PubMed search

66002

64385

ENSG00000186204

ENSMUSG00000024292

Q9HCS2

Q9EP75

NM_023944

NM_001204333
NM_001204334
NM_001204335
NM_001204336
NM_022434

NP_076433

NP_001191262
NP_001191263
NP_001191264
NP_001191265
NP_071879

Cytochrome P450 4F12 is a protein that in humans is encoded by the CYP4F12 gene.

This gene encodes a member of the cytochrome P450 superfamily of enzymes and is part of a cluster of cytochrome P450 genes on chromosome 19. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. CYP4F12 is expressed in the liver and throughout the gastrointestinal track, is known to metabolize the anti-histamine drugs, ebastine and terfenadine, and therefore is suggested to be positioned for and possibly involved in the processing of these and perhaps other drugs.

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Wikipedia