CYP3A7

Identifiers

CYP3A7, CP37, CYPIIIA7, P-450(HFL33), P-450111A7, P450-HFLA, cytochrome P450 family 3 subfamily A member 7

External IDs

MGI: 88610 HomoloGene: 133564 GeneCards: CYP3A7

Gene ontology
Molecular function	• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • aromatase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • iron ion binding • oxidoreductase activity • monooxygenase activity • heme binding • oxygen binding • metal ion binding • steroid hydroxylase activity • estrogen 16-alpha-hydroxylase activity
Cellular component	• endoplasmic reticulum membrane • organelle membrane • intracellular membrane-bounded organelle • membrane • endoplasmic reticulum
Biological process	• xenobiotic metabolic process • lipid hydroxylation • steroid metabolic process • oxidation-reduction process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1551


13113

Ensembl


ENSG00000160870


ENSMUSG00000029727

UniProt


P24462


Q64464

RefSeq (mRNA)


NM_000765


NM_007819

RefSeq (protein)


NP_001243426 NP_000756


NP_031845.1 NP_031845

Location (UCSC)

Chr 7: 99.71 – 99.74 Mb

Chr 5: 137.89 – 137.92 Mb

PubMed search

NP_001243426
NP_000756

NP_031845.1
NP_031845

CYP3A7 is an enzyme belonging to the family. It is 503 amino acids in size and shares 87% of its sequence with CYP3A4. It carries out a similar role in fetuses that CYP3A4 serves in adults. The gene location is 7q22.1.

The CYP3A group of enzymes are the most abundantly expressed members of the cytochrome P450 family in liver. They are responsible for the metabolism of more than 50% of all clinical pharmaceuticals.

The CYP3A7*1C allele is associated with poor outcomes in some cancer patients, possibly because of the effect of the enzyme on some chemotherapy agents.

...
Wikipedia