CYP2U1

Identifiers

CYP2U1, P450TEC, SPG49, SPG56, cytochrome P450 family 2 subfamily U member 1

External IDs

MGI: 1918769 HomoloGene: 77704 GeneCards: CYP2U1

Gene ontology
Molecular function	• iron ion binding • oxidoreductase activity • aromatase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • metal ion binding • oxygen binding • monooxygenase activity • steroid hydroxylase activity
Cellular component	• integral component of membrane • organelle membrane • endoplasmic reticulum membrane • endoplasmic reticulum • membrane • intracellular membrane-bounded organelle
Biological process	• omega-hydroxylase P450 pathway • oxidation-reduction process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


113612


71519

Ensembl


ENSG00000155016


ENSMUSG00000027983

UniProt


Q7Z449


Q9CX98

RefSeq (mRNA)


NM_183075


NM_027816

RefSeq (protein)


NP_898898


NP_082092

Location (UCSC)

Chr 4: 107.93 – 107.95 Mb

Chr 3: 131.29 – 131.3 Mb

PubMed search

CYP2U1 (cytochrome P450, family 2, subfamily U, polypeptide 1) is a protein that in humans is encoded by the CYP2U1 gene

This gene encodes a member of the superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and the hydroxylation of fatty acids and fatty acid metabolites. CYP2U1 metabolized arachidonic acid, docosahexaenoic acid (DHA), and other long chain fatty acids which suggests that CYP2U1 may play a role in brain and immune functions. CYP2U1 also metabolizes propanone, acetone, and 2-oxypropane.

The CYP2U1 gene is a highly conserved gene that is mainly expressed in brain and thymus, but also at lower levels in kidney, lung, and heart.

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Wikipedia