CYP2B6

CYP2B6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IBD, 3QOA, 3QU8, 3UA5, 4I91, 4RQL, 4RRT, 4ZV8
Identifiers
Aliases	CYP2B6, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450, cytochrome P450 family 2 subfamily B member 6, Cytochrome P450 2B6
External IDs	MGI: 88598 HomoloGene: 73894 GeneCards: CYP2B6
Targeted by Drug
ticlopidine
Gene ontology Molecular function • iron ion binding • arachidonic acid epoxygenase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • metal ion binding • monooxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • oxygen binding Cellular component • organelle membrane • endoplasmic reticulum membrane • membrane • intracellular membrane-bounded organelle • endoplasmic reticulum Biological process • steroid metabolic process • exogenous drug catabolic process • epoxygenase P450 pathway • cellular ketone metabolic process • drug metabolic process • xenobiotic metabolic process • oxidation-reduction process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1555	13088
Ensembl	ENSG00000197408	ENSMUSG00000030483
UniProt	P20813	P12791
RefSeq (mRNA)	NM_000767	NM_009999
RefSeq (protein)	NP_000758	n/a
Location (UCSC)	Chr 19: 40.99 – 41.02 Mb	Chr 7: 25.9 – 25.93 Mb
PubMed search

3IBD, 3QOA, 3QU8, 3UA5, 4I91, 4RQL, 4RRT, 4ZV8

1555

13088

ENSG00000197408

ENSMUSG00000030483

P20813

P12791

NM_000767

NM_009999

NP_000758

n/a

Cytochrome P450 2B6 is an enzyme that in humans is encoded by the CYP2B6 gene. CYP2B6 is a member of the group of enzymes. Along with CYP2A6, it is involved with metabolizing nicotine, along with many other substances.

This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide.

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Wikipedia