CYP2A6

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
4RUI, 1Z10, 1Z11, 2FDU, 2FDV, 2FDW, 2FDY, 3EBS, 3T3Q, 3T3R, 4EJJ

Identifiers

Aliases

CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB, cytochrome P450 family 2 subfamily A member 6

External IDs

OMIM: 122720 HomoloGene: 85917 GeneCards: CYP2A6

Gene ontology
Molecular function	• iron ion binding • arachidonic acid epoxygenase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • metal ion binding • monooxygenase activity • steroid hydroxylase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • enzyme binding • oxidoreductase activity • coumarin 7-hydroxylase activity
Cellular component	• organelle membrane • endoplasmic reticulum membrane • membrane • intracellular membrane-bounded organelle • endoplasmic reticulum • cytoplasmic microtubule
Biological process	• steroid metabolic process • exogenous drug catabolic process • epoxygenase P450 pathway • coumarin catabolic process • drug metabolic process • oxidation-reduction process • coumarin metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1548


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Ensembl


ENSG00000255974


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UniProt


P11509


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RefSeq (mRNA)


NM_000762


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RefSeq (protein)


NP_000753


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Location (UCSC)

Chr 19: 40.84 – 40.88 Mb

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PubMed search

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4RUI, 1Z10, 1Z11, 2FDU, 2FDV, 2FDW, 2FDY, 3EBS, 3T3Q, 3T3R, 4EJJ

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Cytochrome P450 2A6 (abbreviated CYP2A6) is a member of the mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. CYP2A6 is the primary enzyme responsible for the oxidation of nicotine and cotinine. It is also involved in the metabolism of several pharmaceuticals, carcinogens, and a number of coumarin-type alkaloids. CYP2A6 is the only enzyme in the human body that appreciably catalyzes the 7-hydroxylation of coumarin, such that the formation of the product of this reaction, 7-hydroxycoumarin, is used as a probe for CYP2A6 activity.

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