CUL4B

CUL4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DO7, 4A0C, 4A0L, 4A64
Identifiers
Aliases	CUL4B, CUL-4B, MRXHF2, MRXS15, MRXSC, SFM2, cullin 4B
External IDs	MGI: 1919834 HomoloGene: 2660 GeneCards: CUL4B
Gene location (Human) Chr. X chromosome (human) Band Xq24 Start 120,524,609 bp End 120,575,794 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band n/a Start 38,533,274 bp End 38,576,196 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • ubiquitin protein ligase activity • damaged DNA binding • protein binding • ubiquitin protein ligase binding Cellular component • cullin-RING ubiquitin ligase complex • nucleoplasm • extracellular exosome • nucleus • cytosol • Cul4B-RING E3 ubiquitin ligase complex • Cul4-RING E3 ubiquitin ligase complex Biological process • positive regulation of protein catabolic process • nucleotide-excision repair, DNA damage recognition • ubiquitin-dependent protein catabolic process • histone H2A monoubiquitination • cellular response to DNA damage stimulus • positive regulation of G1/S transition of mitotic cell cycle • global genome nucleotide-excision repair • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • cell cycle • transcription-coupled nucleotide-excision repair • nucleotide-excision repair, DNA incision • neuron projection development • UV-damage excision repair • DNA damage response, detection of DNA damage • nucleotide-excision repair, preincision complex assembly • nucleotide-excision repair, DNA incision, 3'-to lesion • nucleotide-excision repair, DNA incision, 5'-to lesion • nucleotide-excision repair, DNA duplex unwinding • DNA repair • nucleotide-excision repair, preincision complex stabilization • post-translational protein modification • proteasomal protein catabolic process • protein ubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8450	72584
Ensembl	ENSG00000158290	ENSMUSG00000031095
UniProt	Q13620	A2A432
RefSeq (mRNA)	NM_001079872 NM_003588 NM_001330624	NM_001110142 NM_028288
RefSeq (protein)	NP_001073341 NP_001317553 NP_003579	NP_001103612 NP_082564
Location (UCSC)	Chr X: 120.52 – 120.58 Mb	Chr X: 38.53 – 38.58 Mb
PubMed search

2DO7, 4A0C, 4A0L, 4A64

8450

72584

ENSG00000158290

ENSMUSG00000031095

Q13620

A2A432

NM_001079872
NM_003588
NM_001330624

NM_001110142
NM_028288

NP_001073341
NP_001317553
NP_003579

NP_001103612
NP_082564

Cullin-4B is a protein that in humans is encoded by the CUL4B gene which is located on the X chromosome.CUL4B has high sequence similarity with CUL4A, with which it shares certain E3 ubiquitin ligase functions. CUL4B is largely expressed in the nucleus and regulates several key functions including: cell cycle progression, chromatin remodeling and neurological and placental development in mice. In humans, CUL4B has been implicated in X-linked intellectual disability and is frequently mutated in pancreatic adenocarcinomas and a small percentage of various lung cancers. Viruses such as HIV can also co-opt CUL4B-based complexes to promote viral pathogenesis. CUL4B complexes containing Cereblon are also targeted by the teratogenic drug thalidomide.

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