Cereblon

CRBN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4M91, 4TZ4, 5FQD, 5HXB
Identifiers
Aliases	CRBN, MRT2, MRT2A, Cereblon
External IDs	MGI: 1913277 HomoloGene: 9461 GeneCards: CRBN
Gene ontology Molecular function • protein binding • metal ion binding Cellular component • cytoplasm • Cul4A-RING E3 ubiquitin ligase complex • nucleolus • membrane • nucleus Biological process • negative regulation of protein homooligomerization • positive regulation of protein homodimerization activity • protein ubiquitination • proteasome-mediated ubiquitin-dependent protein catabolic process • negative regulation of ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51185	58799
Ensembl	ENSG00000113851	ENSMUSG00000005362
UniProt	Q96SW2	Q8C7D2
RefSeq (mRNA)	NM_001173482 NM_016302	NM_021449 NM_175357
RefSeq (protein)	NP_001166953 NP_057386	NP_067424 NP_780566
Location (UCSC)	Chr 3: 3.14 – 3.18 Mb	Chr 6: 106.78 – 106.8 Mb
PubMed search

4M91, 4TZ4, 5FQD, 5HXB

51185

58799

ENSG00000113851

ENSMUSG00000005362

Q96SW2

Q8C7D2

NM_001173482
NM_016302

NM_021449
NM_175357

NP_001166953
NP_057386

NP_067424
NP_780566

Cereblon is a protein that in humans is encoded by the CRBN gene. The gene that encodes the cereblon protein is found on the human chromosome 3, on the short arm at position p26.3 from base pair 3,190,676 to base pair 3,221,394. CRBN orthologs are highly conserved from plants to humans.

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