CTLA4

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3OSK, 1AH1, 1H6E, 1I85, 1I8L, 2X44, 3BX7

Identifiers

CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 4

External IDs

Gene ontology
Molecular function	• protein binding
Cellular component	• perinuclear region of cytoplasm • integral component of membrane • clathrin-coated endocytic vesicle • plasma membrane • Golgi apparatus • membrane • external side of plasma membrane • protein complex involved in cell adhesion • integral component of plasma membrane
Biological process	• B cell receptor signaling pathway • T cell costimulation • negative regulation of B cell proliferation • adaptive immune response • negative regulation of regulatory T cell differentiation • immune response • cellular response to DNA damage stimulus • immune system process • positive regulation of apoptotic process • negative regulation of immune response • negative regulation of T cell proliferation • regulation of regulatory T cell differentiation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1493


12477


ENSG00000163599


n/a


P16410


P09793

RefSeq (mRNA)


NM_001037631 NM_005214


NM_001281976 NM_009843

RefSeq (protein)


NP_001032720 NP_005205


NP_001268905 NP_033973

Location (UCSC)

PubMed search

n/a

[The language of this article is too technical. Help us improve it.]

CTLA4 or CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152 (cluster of differentiation 152), is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses. CTLA4 is constitutively expressed in Tregs but only upregulated in conventional T cells after activation. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.