CREB3

CREB3
Identifiers
Aliases	CREB3, LUMAN, LZIP, sLZIP, cAMP responsive element binding protein 3
External IDs	MGI: 99946 HomoloGene: 31375 GeneCards: CREB3
Gene ontology Molecular function • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • protein homodimerization activity • protein dimerization activity • cAMP response element binding protein binding • transcription factor activity, sequence-specific DNA binding • CCR1 chemokine receptor binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • chromatin binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • cAMP response element binding Cellular component • cytoplasm • integral component of membrane • Golgi apparatus • nuclear body • endoplasmic reticulum membrane • membrane • integral component of endoplasmic reticulum membrane • neuronal cell body • endoplasmic reticulum • nucleus • cytosol • Golgi membrane • nucleoplasm Biological process • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • negative regulation of ligand-dependent nuclear receptor transcription coactivator activity • regulation of transcription, DNA-templated • release from viral latency • positive regulation of cell migration • cytoplasmic sequestering of transcription factor • negative regulation of cell cycle • positive regulation of monocyte chemotaxis • transcription, DNA-templated • response to endoplasmic reticulum stress • induction of positive chemotaxis • positive regulation of transcription, DNA-templated • chemotaxis • response to unfolded protein • regulation of cell proliferation • regulation of cell growth • establishment of viral latency • positive regulation of deacetylase activity • positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response • viral process • positive regulation of transcription from RNA polymerase II promoter • positive regulation of defense response to virus by host • positive regulation of calcium ion transport • transcription from RNA polymerase II promoter • endoplasmic reticulum unfolded protein response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10488	12913
Ensembl	ENSG00000107175	ENSMUSG00000028466
UniProt	O43889	Q61817
RefSeq (mRNA)	NM_006368	NM_013497
RefSeq (protein)	NP_006359	n/a
Location (UCSC)	Chr 9: 35.73 – 35.74 Mb	Chr 4: 43.56 – 43.57 Mb
PubMed search

10488

12913

ENSG00000107175

ENSMUSG00000028466

O43889

Q61817

NM_006368

NM_013497

NP_006359

n/a

Cyclic AMP-responsive element-binding protein 3 is a protein that in humans is encoded by the CREB3 gene.

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.

CREB3 has been shown to interact with Host cell factor C1.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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