CMKLR1

Identifiers

CMKLR1, CHEMERINR, ChemR23, DEZ, RVER1, chemerin chemokine-like receptor 1

External IDs

Genetically Related Diseases

Gene ontology
Molecular function	• G-protein coupled receptor activity • protein binding • chemokine receptor activity • signal transducer activity • receptor activity
Cellular component	• integral component of membrane • plasma membrane • integral component of plasma membrane • membrane
Biological process	• chemotaxis • skeletal system development • G-protein coupled receptor signaling pathway • positive regulation of macrophage chemotaxis • negative regulation of NF-kappaB transcription factor activity • positive regulation of fat cell differentiation • immune response • regulation of calcium-mediated signaling • signal transduction • negative regulation of interleukin-12 production • chemokine-mediated signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1240


14747


ENSG00000174600


ENSMUSG00000042190


Q99788


P97468

RefSeq (mRNA)


NM_004072 NM_001142343 NM_001142344 NM_001142345


NM_008153

RefSeq (protein)


NP_001135815 NP_001135816 NP_001135817 NP_004063


NP_032179.1 NP_032179

Location (UCSC)

PubMed search

Chemokine like receptor 1 also known as ChemR23 (Chemerin Receptor 23) is a protein that in humans is encoded by the CMKLR1 gene. Chemokine receptor-like 1 is a G protein-coupled receptor for the chemoattractant adipokine chemerin and the omega-3 fatty acid eicosapentaenoic acid-derived specialized pro-resolving molecule, resolvin E1 (see Specialized proresolving mediators#EPA-derived resolvins (i.e. RvE)). The murine receptor that shares almost 80% homology with the human receptor, is called Dez.