CK8

KRT8
Identifiers
Aliases	KRT8, CARD2, CK-8, CK8, CYK8, K2C8, K8, KO, keratin 8
External IDs	OMIM: 148060 MGI: 96705 HomoloGene: 55643 GeneCards: KRT8
Gene ontology Molecular function • protein complex binding • scaffold protein binding • structural molecule activity • protein binding Cellular component • cytoplasm • cell-cell junction • nuclear matrix • dystrophin-associated glycoprotein complex • keratin filament • nucleoplasm • Z disc • sarcolemma • costamere • extracellular exosome • intermediate filament • nucleus • cell periphery • cytosol • apicolateral plasma membrane • intermediate filament cytoskeleton Biological process • extrinsic apoptotic signaling pathway • response to hydrostatic pressure • tumor necrosis factor-mediated signaling pathway • response to other organism • viral process • cell differentiation involved in embryonic placenta development • sarcomere organization • hepatocyte apoptotic process • keratinization • cornification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3856	16691
Ensembl	ENSG00000170421	ENSMUSG00000049382
UniProt	P05787	P11679
RefSeq (mRNA)	NM_001256282 NM_001256293 NM_002273	NM_031170
RefSeq (protein)	NP_001243211 NP_001243222 NP_002264	NP_112447.2 NP_112447
Location (UCSC)	Chr 12: 52.9 – 52.95 Mb	Chr 15: 102 – 102 Mb
PubMed search

3856

16691

ENSG00000170421

ENSMUSG00000049382

P05787

P11679

NM_001256282
NM_001256293
NM_002273

NM_031170

NP_001243211
NP_001243222
NP_002264

NP_112447.2
NP_112447

Keratin, type II cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that is encoded in humans by the KRT8 gene. It is often paired with keratin 18.

Antibodies to CK8 (e.g. CAM 5.2) can be used to differentiate lobular carcinoma of the breast from ductal carcinoma of the breast. CAM 5.2, an antibody that reacts with an epitope found on both CK8 and CK18, is used in to demonstrate certain forms of cancer. In normal tissue, it reacts mainly with secretory epithelia, but not with squamous epithelium, such as that found in the skin, cervix, and esophagus. However, it also reacts with a range of malignant cells, including those derived from secretory epithelia, but also some squamous carcinomata, such as spindle cell carcinoma. It is considered useful in identifying microscopic metastases of breast carcinoma in lymph nodes, and in distinguishing Paget's disease from malignant melanoma. It also reacts with neuroendocrine tumors.

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Wikipedia