CHRNA4

CHRNA4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LLY
Identifiers
Aliases	CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4, cholinergic receptor nicotinic alpha 4 subunit
External IDs	MGI: 87888 HomoloGene: 592 GeneCards: CHRNA4
Targeted by Drug
rivanicline, hexamethonium, mecamylamine
Gene ontology Molecular function • acetylcholine binding • acetylcholine receptor activity • ion channel activity • ligand-gated ion channel activity • extracellular ligand-gated ion channel activity • protein binding • acetylcholine-gated cation-selective channel activity Cellular component • integral component of membrane • acetylcholine-gated channel complex • postsynaptic membrane • membrane • plasma membrane • synapse • cell junction • neuronal cell body • dendrite • external side of plasma membrane Biological process • regulation of dopamine secretion • inhibitory postsynaptic potential • response to hypoxia • cognition • locomotory behavior • regulation of membrane potential • response to nicotine • membrane depolarization • neurological system process • synaptic transmission, cholinergic • ion transport • response to oxidative stress • respiratory gaseous exchange • behavioral response to nicotine • B cell activation • neuromuscular synaptic transmission • exploration behavior • transport • action potential • sensory perception of pain • DNA repair • calcium ion transport • signal transduction • chemical synaptic transmission • excitatory postsynaptic potential • acetylcholine receptor signaling pathway • cation transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1137	11438
Ensembl	ENSG00000101204	ENSMUSG00000027577
UniProt	P43681	O70174
RefSeq (mRNA)	NM_000744 NM_001256573	NM_015730
RefSeq (protein)	NP_000735 NP_001243502	NP_056545.3 NP_056545
Location (UCSC)	Chr 20: 63.34 – 63.38 Mb	Chr 2: 181.02 – 181.04 Mb
PubMed search

2LLY

1137

11438

ENSG00000101204

ENSMUSG00000027577

P43681

O70174

NM_000744
NM_001256573

NM_015730

NP_000735
NP_001243502

NP_056545.3
NP_056545

Neuronal acetylcholine receptor subunit alpha-4, also known as nAChRα4, is a protein that in humans is encoded by the CHRNA4 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. After binding acetylcholine, these pentameric receptors respond by undergoing an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The protein encoded by this gene is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene appear to account for a small proportion of the cases of nocturnal frontal lobe epilepsy.

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Wikipedia