CDKL5

CDKL5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BGQ
Identifiers
Aliases	CDKL5, EIEE2, ISSX, STK9, CFAP247, cyclin dependent kinase like 5
External IDs	OMIM: 300203 MGI: 1278336 HomoloGene: 55719 GeneCards: CDKL5
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • Rac GTPase binding • kinase activity • protein serine/threonine kinase activity • ATP binding • cyclin-dependent protein serine/threonine kinase activity Cellular component • dendritic growth cone • nucleoplasm • ruffle membrane • nucleus • cytosol • dendrite cytoplasm • synapse • perinuclear region of cytoplasm Biological process • phosphorylation • neuron migration • protein phosphorylation • positive regulation of GTPase activity • positive regulation of dendrite morphogenesis • protein autophosphorylation • positive regulation of axon extension • regulation of dendrite development • positive regulation of dendritic spine development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6792	382253
Ensembl	ENSG00000008086	ENSMUSG00000031292
UniProt	O76039	Q3UTQ8
RefSeq (mRNA)	NM_001037343 NM_003159 NM_001323289	NM_001024624
RefSeq (protein)	NP_001032420 NP_001310218 NP_003150	NP_001019795.1 NP_001019795
Location (UCSC)	Chr X: 18.43 – 18.65 Mb	Chr X: 160.77 – 160.99 Mb
PubMed search

4BGQ

6792

382253

ENSG00000008086

ENSMUSG00000031292

O76039

Q3UTQ8

NM_001037343
NM_003159
NM_001323289

NM_001024624

NP_001032420
NP_001310218
NP_003150

NP_001019795.1
NP_001019795

CDKL5 is a gene that provides instructions for making a protein called cyclin-dependent kinase-like 5 also known as serine/threonine kinase 9 (STK9) that is essential for normal brain development with mutations causing deficiencies in the protein level. It regulates neuronal morphology through cytoplasmic signaling and controlling gene expression. The CDKL5 protein acts as a kinase, which is an enzyme that changes the activity of other proteins by adding a cluster of oxygen and phosphorus atoms (a phosphate group) at specific positions. Researchers are currently working to determine which proteins are targeted by the CDKL5 protein.

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